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ICD-10-CM Code D51.0 Definition and Clinical Description The CDC ICD-10-CM web tool defines D51.0 as Vitamin B12 deficiency anemia due to intrinsic factor deficiency. This medical classification captures a specific pathophysiology: autoimmune destruction of gastric parietal cells reduces intrinsic factor production, which prevents B12 binding and absorption in the terminal ileum

Cultured hepatocytes exhibit basal GCLC phosphorylation, which increased when treated with DBcAMP or phenylephrine, suggesting GCLC may be under a basal inhibitory tone [128]

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