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2.3 Other hazards Results of PBT and vPvB assessment PBT: Not applicable

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Chu B, Kon N, Chen D, Li T, Liu T, Jiang L, Song S, Tavana O, Gu W

doi: 10.1124/jpet.106.104026 51 ClearyDBEhringerWDMaurerMC

1H NMR determination of urinary betaine in patients with premature vascular disease and mild homocysteinemia

CB-839 (Telaglenastat), a potent, reversible, and selective small-molecule inhibitor that targets GLS-1 and has a half-maximal inhibitory concentration (IC 50 ) of 24 nM for recombinant human glutaminase C, has been investigated in solid tumors and in AML, diffuse large B-cell lymphoma, and multiple myeloma cells alone or in combination with other anticancer drugs (10, 11, 2026)