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Redoxosomes contain redox proteins that are involved in transmitting ROS signals from interior to outer membranes, and they regulate ROS as a secondary messenger (Oakley et al., 2009)

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Stockwell et al., Ferroptosis: An iron-dependent form of nonapoptotic cell death., Cell , 2012 , 149(5), 1060

These findings collectively suggest a plausible mechanism whereby GSDMD-N could be transferred indirectlypotentially via extracellular vesiclesfrom supporting cells to hair cell membrane and directly inducing pyroptosis

Therefore, strategies for mitochondria-mediated ferroptosis in IDD exhibit notable research and application potential (Fig

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