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DOI: 10.1597/08-270.1 4

Konopleva, M, Zhao S, Xie Z, Segall H, Younes A, Claxton DF, Estrov Z, Kornblau SM, Andreeff M

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Concurrent advancements in epigenetic editing and organelle-specific delivery systems can redefine therapeutic precision, enabling spatiotemporal control over lipid metabolic fluxes while minimizing off-target effects associated with conventional enzyme inhibitors

In a systematic review, the median duration of cannabis use before the onset of CHS symptoms was 42 months and the median age of starting cannabis use in patients with CHS was 16 years.40 Duration of cannabis use was reported to be 1 year for 25.1%, 2-5 years for 36.3%, 6-10 years for 16.8%, and 11 years for 21.8% of patients