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VEGF-A binds to both VEGFR-1 and VEGFR-2, but mainly signals through VEGFR-2 (33)

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Although other therapeutic agents, such as colivelin, have been shown to restore the glycocalyx and reduce the plasma concentration of syndecan-1 in sepsis (127), it is not clear whether these agents are directly integrated into the glycocalyx from the circulation or whether the glycocalyx is restored by de novo synthesis by endothelial cells

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These findings were supported by the results of weighted-gene co-expression network analysis (WGCNA) revealing the enrichment of MWM-cognitive-performance-correlating gene modules with very similar Gene Ontology terms
