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Tissue distribution radiolabel-based or MS-based tissue distribution studies

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Blockade of Eotaxin/Oncostatin M not only prevented hypoxic breast tumor cells from recruiting and polarizing macrophages towards the M2-like phenotype and hindered cancer progression in 4T1 breast cancer model but also improved the efficacy of antiangiogenic Bevacizumab, suggesting these two cytokines as novel targets for devising effective anticancer therapy (293)

Given that an average rat weighing 200 g drinks approximately 4050 ml/day [120], it would consume 3645 mg of NAC daily, corresponding to 180225 mg/kg/day

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