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The synergy stems from complementary mechanisms

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You will need to recalculate units for the split dose: at 10mg/mL concentration, each 4mg injection is 40 units

In fact, some preclinical animal studies have explored potential protective effects involving kidney tissue and circulation

Neelakantan H, Vance V, Wetzel MD, Wang HY, McHardy SF, Finnerty CC, Hommel JD, Watowich SJ. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high-fat diet-induced obesity in mice. Biochem Pharmacol. 2018 Jul;154:161-171. doi: 10.1016/j.bcp.2018.05.003. Epub 2018 May 5. PMID: 29738706; PMCID: PMC6015571

Its possible for side effects to come back when you increase your dose