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In a study focusing on triazole analogs as selective COX-2 inhibitors, a comparative molecular field investigation was conducted to explore the SAR, and pharmacophores with effective anti-inflammatory properties were identified

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In response to the damage, mitogenic cyokines are secreted and a similar process to wound healing results in rapid cell cycling and rapid maturation of keratinocytes [1, 2, 3].The constant inflammatory cell chemotaxis and cytokine release causes the chronic clinical course with recurrent lesions

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All authors have read and approved the final manuscript

Foekens, J