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Active metabolite characterisation whether smaller peptide fragments retain biological activity

Triacylglycerol, diacylglycerol and ceramides were all substantially elevated in muscle from female mice lacking ER globally or specifically in muscle

A growing body of clinical research indicates that exercise interventions can markedly enhance cognitive performance, motor function, and overall quality of life in individuals with NDDs (Santamara et al., 2025)

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Future clinical trials and translational studies are required to better evaluate these interventions and establish comprehensive treatment protocols for METH users

Statements Author contributions MK and MU conceived the original idea and designed the outlines of the study and prepared the figures for the manuscript