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This accumulation depletes the other types of folate required for purine and thymidylate synthesis, which are required for the synthesis of DNA

It has also been shown that coronavirus infection can inhibit the activity of numerous karyopherin-dependent host transcription factors including the vitamin D receptor (VDR) and hypoxia-inducible factor 2 [HIF2]-Epas, p53 in human lung cells [109]

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[DOI] [PMC free article] [PubMed] [Google Scholar] Pardes AM, Freedman BR, Fryhofer GW, Salka NS, Bhatt PR, Soslowsky LJ (2016) Males have inferior achilles tendon material properties compared to females in a rodent model