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doi: 10.1161/01.ATV.0000222015.76038.14

This cross-linking can lead to aggregation, where individual peptide molecules clump together into larger, inactive structures

The transcription factor cAMP response element modulator (CREM) is highly expressed in male germ cells and regulates the expression of several post-meiotic genes, such as the transition proteins and protamines, and it likely is the key regulator of gene expression during spermatogenesis

Ballatori N, Hammond CL, Cunningham JB, Krance SM, Marchan R

Some people feel a temporary shift in energy or digestion

Neural mechanisms, such as neurogenic inflammation, are also important in NHIC, where nerve activation exacerbates bladder pain