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In the Haber-Weiss cycle, OH is generated through the interaction of superoxide anion (O 2 ) and H 2 O 2

We therefore examined TXNIP and MafA expression in -cell

Hypoxia not only causes the accumulation of immunosuppressive metabolites (such as adenosine and lactic acid) in solid tumors, but also restricts the infiltration of immune cells, thus inhibiting the bodys anti-tumor immune responses

Abstract Glyoxalase pathway, comprising glyoxalase I (GLY I) and glyoxalase II (GLY II) enzymes, is the major pathway for detoxification of methylglyoxal (MG) into D-lactate involving reduced glutathione (GSH)

10.3390/ijms23052441 110 OredssonS.Malakpour-PermlidA.ZhuJ.WeberT

Prior to the experiment, the cells were cultured for four days to become fully confluent