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Family history of T2DM has also been linked to increased vulnerability to oxidative stress and inflammatory phenotypes [1226]
The decreased expression of TF in oligodendrocytes in the SN of PD patients may decrease the ability of oligodendrocytes to sequester excess iron, ultimately resulting in an increase in oxidative stress in dopaminergic neurons
Respirology (2016) 21(5):9517
Cancer Cell 24(4):450465
Human frataxin, the Friedreich ataxia deficient protein, interacts with mitochondrial respiratory chain
Fusing six-membered rings at positions C-6 and N-7 substantially improved PDE1 potency
