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The NHS notes that taking up to 2,000 micrograms daily is unlikely to cause harm in most people, though there is generally no benefit to such excessive amounts without confirmed deficiency

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Abcb7, the gene responsible for X-linked sideroblastic anemia with ataxia, is essential for hematopoiesis

Unlike with oral supplements, due to the breakdown by stomach and enzymes only portion of the medication are absorbed by the body, that weakens its potency and efficacy