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Poor circulation, which is more likely from age, tight clothing or boots, cramped positions, fatigue, certain medications, smoking, and alcohol

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Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid

The risk factors for PND are multifaceted and may be related to age, infection, preexisting cognitive disorders, surgery duration, anesthetic management, tissue damage, psychological stress and genetic susceptibility (Subramaniyan and Terrando, 2019