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442 Additionally, acetylation of the chromatin remodeling protein MORC family CW-type zinc finger 2 (MORC2) can activate the G2 checkpoint and induce DNA damage, thereby improving the radiosensitivity of breast cancer cells 443 (Fig

Furthermore, they act as signaling units that modulate several functions including protection from apoptosis and inhibition of cell growth

Researchers must also generate non-clinical evidence demonstrating that the compound interacts with the intended target and produces the expected pharmacological effects without showing major safety concerns

Varga D, Hoegel J, Maier C, Jainta S, Hoehne M, Patino-Garcia B, Michel I, Schwarz-Boeger U, Kiechle M, Kreienberg R, Vogel W: On the difference of micronucleus frequencies in peripheral blood lymphocytes between breast cancer patients and controls

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