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Post-Surgical Patients Patients who have undergone certain types of surgeries, particularly those involving the gastrointestinal tract, may experience difficulties with B12 absorption

Sbodio et al ., 2018) (Figure 2B)

1j and Extended Data Fig

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For example, in models of emphysema or chronic obstructive conditions, it has been proposed that the peptide may reverse gene expression signatures and restore activity in pathways such as Transforming Growth Factor-beta and extracellular matrix remodeling

These differentiated cells are capable of synthesizing type II collagen and proteoglycans, improving the ECM, and restoring IVD height (Sakai et al., 2005)