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Its clinical manifestations include motor symptoms, such as bradykinesia, resting tremor, myotonia, and postural balance disorders, and non-motor symptoms, such as hyposmia, sleep disturbance, constipation, and mental and cognitive impairment (1)

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Notice that alpha () and gamma () motoneurons are controlled by descending pathways

Cagrilintide's half-life of approximately seven days allows for flexible dosing windows (administration can be delayed by 12 days without loss of efficacy), but missed doses beyond five days require restarting the titration schedule to avoid rebound nausea

[70] PKC/PKA may, instead, phosphorylate GRKs, which can also lead to GPCR phosphorylation and -arrestin binding in an occupation-independent manner