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Studies in Crat knockout mice demonstrated that CrAT deficiency leads to abnormal fuel selection, which results in a perturbation of glucose homeostasis and suggest that deficits in CrAT activity might contribute to diet-induced metabolic inflexibility by exacerbating the Randle glucose-fatty acid cycle 66

The process of selecting papers, data collection as well as the quality assessment was performed independently by two authors (A.S., G.R.), and all disagreements were resolved by the discussion with the third author (R.O)
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Foitzik, K., Hoting, E., Heinrich, U., Tronnier, H., and Paus, R

doi: 10.1016/s0006-8993(98)00319-9

[DOI] [PMC free article] [PubMed] [Google Scholar] 75.Wolff JA, Carroll JE, Le Phuc T, Prodanos C, Haas R, Nyhan WL

J Am Coll Cardiol 1995;26:1411-6
