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First, as alluded to above, restoration of wild type function to mutant p53 by APR-246 might increase sensitivity to chemotherapeutic drugs that depend on wild type p53 for induction of efficient tumor cell apoptosis

Mater 13, e2302773

Ultimately, this assists GPX4 in exerting its antioxidant effects

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and prepulse (repeated measures: % PPI 76p110, % PPI 80p110, % PPI 88p110) and treatment (three levels: WT PBS, Tbx1 +/ PBS, and Tbx1 +/ vB12)

QM wrote the draft