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Another possible reason is that NNMT may deplete redundant NAM in cardiocytes and smooth muscle cells, to enhance PARPs activities for DNA repair

Its a key nutrient that helps in the formation of red blood cells and DNA synthesis

A diagnostic trial utilizing physiologic doses of vitamin B12 (1 mcg daily) and observing daily reticulocyte counts after establishing a baseline may also be performed

As described above, there is compelling evidence that significant tissue-level cobalamin deficiency is present in some companion animal patients with gastrointestinal disease

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For those requiring B12 for legitimate medical reasons, adjusting the dose or formulation may help, though only under medical supervision