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IGF-1 has specific and stimulatory effects on granulosa cells, and it was reported to increase the expression of steroidogenic enzymes CYP11A1, 3-hroxysteroid dehydrogenase (3HSD), CYP19A1, along with IGF-1R, and FSHR gene expression (70)

[DOI] [PMC free article] [PubMed] [Google Scholar] 26.Shanthi P.T., Foes A., Munirathinam G

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These observations should be considered hypothesis-generating and warrant further investigation in well-designed longitudinal and interventional human studies

By stopping your thyroid from going into overdrive and reducing your Graves symptoms, we can help you feel calmer, get more restful sleep, and stay more energized, along with supporting eye health and keeping you at a healthy weight.

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