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When autophagy is dysfunctional, it causes intracellular p62 accumulation, leading to the activation of the Nrf2 pathway and thus compensating for the lack of autophagy [83, 84]

This introduces the question of injection volume management

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Safety data is similarly limited, with the tolerability of creams and long-term effects sparsely analyzed in the literature

References Anderson, J.M., et al

Lipid peroxidation and antioxidants in plasma and red blood cells from patients with pemphigus vulgaris J Basic Clin Physiol Pharmacol