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The molecular mechanism involves the PI3K/AKT1 pathway, a major cell survival signaling cascade

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The polymorphic variations in the GSS gene directly correlate with the enzymes function, influencing the cellular antioxidant capacity and the ability to combat oxidative stress ( The GLUL gene encodes the enzyme glutamate ammonia ligase, also known as glutamine synthetase

2) Functional impairment characterized by universal depletion of anti-inflammatory, SCFA-producing genera including Faecalibacterium , Blautia , and Bifidobacterium

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[DOI] [PMC free article] [PubMed] 161.Cakmak YO