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Clinics generally advise against starting treatment for anyone who: Is pregnant Has a personal or family history of thyroid cancer Has a history of multiple endocrine neoplasia (MEN) syndrome BMI and health history serve as a useful starting point for this evaluation, not an absolute cutoff, since metabolism and overall wellness also weigh into a provider's decision

PubMed: 18283677 Pharmacokinetics and Bioavailability of AOD 9604 in Healthy Subjects human pilot Wallace JD, Cuneo RC, Lundqvist G, et al

The main difference is the route of administration

Hormone Research Heffernan M et al

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Most of these effects appeared during the dose escalation phase and resolved within the first 12 weeks