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It was originally isolated from a bovine thymus extract in 1975 by Goldstein (1975)

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J Clin Invest 113:96105 Brismar K, Gutniak M, Povoa G, Werner S, Hall K (1988) Insulin regulates the 35 kDa IGF binding protein in patients with diabetes mellitus
Human Evidence Human research primarily involves topical application

Astaxanthin eliminates free radicals from the body, and protects skin from oxidative damage which can cause fine lines and wrinkles