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Extra caution is appropriate in patients with active cancer, recent cancer, unexplained masses, unexplained weight loss, pregnancy, breastfeeding, known allergy to peptide products, active infection, immune compromise, significant liver or kidney disease, active inflammatory or autoimmune disease flares, unusual clotting history, uncontrolled cardiovascular disease, use of chemotherapy or immune-modifying biologic therapy, and competitive athletes subject to anti-doping rules

Patients with Lebers disease should avoid using it also

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What does NAD+ do in the body

Some research suggests NAD+ precursors may improve insulin sensitivity in animal models, but translation to human metabolic disorders remains unproven