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The combination produced a mean weight reduction of 20.4% under the treatment-policy estimand, versus 3.0% with placebo (-17.3% difference
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Whether thats a dose issue, a formulation issue, the difficulty of controlling for diet and exercise, or a ceiling on what this mechanism can actually achieve in humans is still somewhat open

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Research published in Arthritis Research & Therapy highlights the potential of certain peptides to reduce joint inflammation and slow disease progression