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These multilayered regulatory effects may be particularly relevant in the subacute and chronic phases of stroke recovery, where cellular plasticity, angiogenesis, and synaptic remodeling predominate

doi: 10.21037/atm-20-3768

In this study, the investigator assessing photographs was blinded, but patients knew whether they received the active serum or saline

Bittner et al., 2005)

On the one hand, this means they are typically safe at doses much higher than the RDA, but on the other hand, they require a more consistent consumption than the fat soluble vitamins