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To qualify, participants had to be between 18 and 50 years old, have no history of chronic disease, and do at least one hour of regular physical activity per week

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This clinical review critically examines the strengths and limitations of RCTs and RWE, synthesizing statistical findings and published literature to clarify their respective contributions to evidence development

1 Deficiencies of methylfolate and vitamin B12 can lead to decreased SAMe levels, which has been associated with both mental illnesses such as depression and neurodegenerative disorders such as dementia

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