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When activated by SCFAs, GPR43 signaling initiates a cascade that suppresses nuclear factor-kappa B (NF-B) activation, thereby reducing the production of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-) and interleukin-6 (IL-6) (Chen et al., 2019)

This includes vegans, vegetarians, those with pernicious anaemia, malabsorption disorders, or previous gastrointestinal surgery

EphB4-ephrinB2 signalling was also associated with increased tumor angiogenesis and tumor progression [166] as well as with resistance to anti-angiogenic therapy [167]

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I., & Igarashi, K