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Slowing disease progression ALS is a neurological disease characterized by the progressive loss of motor neurons, the nerve cells that control voluntary movement

The PS for adjustment of toxicities was composed using body surface area, age, histology, relapse after surgical resection, ECOG-PS, comorbidities, chemotherapy line, reduced dosage requirement status, and duration of premedication as independent variables, and the C-statistic of the ROC curve analysis was 0.808

Vukojevic et al., 2022)

Clearance of a drug is the factor that predicts the rate of elimination in relation to the drug concentration (C): Clearance, like volume of distribution, may be defined with respect to blood (CL b ), plasma (CL p ), or unbound in water (CL u ), depending on where and how the concentration is measured

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