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Supplementary Video 2 (download MP4 Rotating overlay of predicted reduced and oxidized cofilin-1 models, illustrating oxidation-associated conformational changes and the disulfide bond between Cys 39 and Cys 80

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TdGSH prevented LOsG-induced functional failure of dedifferentiated -cell via the FoxO1/TXNIP pathway Pancreatic -cell dedifferentiation is one of the mechanisms resulting in diabetic -cell failure

Retatrutide has higher rates across the board, plus a new safety signal not seen with tirzepatide

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