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doi: 10.3109/10837450.2014.979944
3 A defect in the RBCs that changes the membrane geometry, its elasticity, or the viscosity of the cytoplasm affects RBC deformability and can result in premature hemolysis and anemia
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Together with the fact that the intestinal lumen diameter is much greater in humans than in mice, this observation suggests that pharmacological claudin-2 channel inhibition is unlikely to cause intestinal obstruction in humans
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