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The CD44v9 is active though increasing the intracellular levels of glutathione (GSH) when combined with the functional subunit of the cystine/glutamate transporter (xCT), resulting in cellular protection from reactive oxygen species (ROS) and oxidative stress, which is one of the distinct characteristics of CSCs [72, 73]

doi: 10.3390/ijms23052702 63 YahyapourRMotevaseliERezaeyanAAbdollahiHFarhoodBChekiMet al

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Ann Neurol 24:446449 Malessa S, Leigh PN, Bertel O, Sluga E, Hornykiewicz O (1991) Amyotrophic lateral sclerosis: glutamate dehydrogenase and transmitter amino acids in the spinal cord

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Furthermore, while probiotics appear to be generally safe, their effects can be strain-specific, and long-term use or potential interactions with other medications require careful consideration