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The several possible routes by which peptides could penetrate the BBB are diffusion, receptor-mediated endocytosis, and carrier-mediated uptake

Furthermore, the use of gene editing technology to knockdown or overexpress CaMKK2 may provide a more definitive assessment of its critical role

GSH deficiency can interfere with the body's ability to detoxify the cellular microenvironment, fold proteins, replenish antioxidants, maintain healthy immune responses and even modulate apoptotic events, promoting suboptimal cellular function and development of diseases [53]

These intermediates can directly substitute for glutamine to amplify lipid ROS accumulation and cell death, ultimately exacerbating the ferroptotic effect

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