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Formulation strategies that extend nasal residence time or enhance epithelial transport may also facilitate dose reduction while preserving therapeutic efficacy (Illum, 2003

However, there was no notable increase in the number of bacteria in the acidified compartments in granulomas solely treated with INH (Figure 3H)

Philos Trans R Soc Lond B Biol Sci 360:23352345

[Prog Abstr] [Google Scholar] 99.Zhu YS, Cai LQ, Huang Y, Imperato-McGinley J

Epilepsy can develop at any age, but it is often diagnosed in childhood or the elderly population

It holds promise for addressing the challenges posed by multiple and extensively drug-resistant Mycobacterium tuberculosis strains, which are increasingly difficult to treat using conventional therapies
