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While bulk acetic acid is still predominantly produced via petrochemical methanol carbonylation, food-grade and specialty acetic acid is exclusively obtained through microbial fermentation, and bio-based acetic acid is increasingly explored as a renewable alternative for polymer, textile, and pharmaceutical applications [86,98]

Funding This work was supported by the Innovative Research Group Program of National Science Foundation of China (Grant No

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Understanding the molecular mechanisms involved in drug resistance remains an important area of research for identification of precise targets and drug discovery to improve therapeutic outcomes