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Although the exact mechanisms have not been elucidated in pathogenesis of autoimmune ILDs, macrophages being the chief cells of innate immunity, are involved in exaggerated inflammatory response, defective efferocytosis, presenting self antigens, and releasing profibrotic cytokines and chemokines

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Additionally, guided bone regeneration materials in oral and maxillofacial surgery such as resorbable collagen membranes and demineralized freeze-dried bone powders as well as titanium nanotube implants, can also be used as bone scaffolds for the delivery of NAC (Yamada et al., 2011

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