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1a), treatment with Ht-PreHNE(alkyne), washout of excess unbound probe and light exposure liberates HNE(alkyne) ( t 1/2 photouncaging 90% silencing efficiency in both KO lines

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In 2004, however, a small retrospective study evaluated the survival of LS patients with stage III colon cancers who received adjuvant treatment with 5-fluorouracil and found no significant differences in colon cancerspecific survival or disease-free survival between individuals receiving adjuvant treatment and those who did not undergo treatment with chemotherapy [115]

on the other hand, excess copper induces high levels of ROS through the Fenton reaction, leading to severe oxidative damage in proteins, lipids, and DNA (Guo et al., 2025)

Effects and mechanisms of taurine as a therapeutic agent

EBI2 is expressed in glial cells in multiple sclerosis lesions, and its knock-out modulates remyelination in the cuprizone model