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Thus, patients with HIV have impaired cell-mediated immunity and increased susceptibility to other deadly opportunistic diseases such as TB, candidiasis, and neurodegenerative diseases

During iron scarcity, the IRE-IRP system also downregulates proteins associated with iron usage [37], including the haem synthesis protein, 5-aminolevulinic acid synthase (ALAS)-2 [38], and the tricarboxylic acid (TCA) cycle enzyme, mitochondrial aconitase 2 (ACO2), which requires a [2Fe-2S] cluster for catalysis [39]

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4 This is thought to be due to diets high in phytates from cereal grains, which hinders the absorption of zinc

10.1002/iub.2020 [DOI] [PubMed] [Google Scholar] Springett G

An early clinical trial in 13 patients with type 2 diabetes found that a single intravenous infusion of 1,000 mg of lipoic acid improved insulin-stimulated glucose disposal (i.e., insulin sensitivity) by 50% compared to a placebo infusion (57)