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Most high-quality studies show only minor effects for healthy individuals, and these changes usually happen alongside other healthy habits like improved diet and increased exercise

Free Radic Biol Med 124:541549 [DOI] [PubMed] [Google Scholar] Li CK, Baker K, Jones T, Coulson E, Roberts A, Birrell F (2021a) Safety and tolerability of subcutaneous methotrexate in routine clinical practice

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Still clinically insignificant, but the percentage error is larger