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doi: 10.1186/s12968-017-0350-x 14 DaubertMAAdamsKYowEBarnhartHXDouglasPSet al

This approach provides both the systemic gene expression modulation from injections and concentrated local delivery from topical application

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The Wnt/-catenin signaling pathway plays a dual role in DKD pathogenesis: its moderate activation protects against hyperglycemia-induced mesangial apoptosis, while chronic overactivation exacerbates renal fibrosis, podocyte injury, and tubular dysfunction

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