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Look for methylated B12 (methylcobalamin), hydroxocobalamin, adenosylcobalamin or a supplement with a combination of these forms.* *A note on cyanocobalamin: Cyanocobalamin is the most commonly used form of B12 in supplements, however it is of questionable safety

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The lack of stability of the double mutant suggests the complete loss of the R-domain-NBD1 interface