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The mainstream pharmaceutical approach, exemplified by tirzepatide and bremelanotide, emphasizes rigorous FDA approval pathways, large-scale randomized controlled trials, and treatment of specific age-related diseases ( In contrast, the longevity medicine approach, prevalent in anti-aging clinics and compounding pharmacy networks, views aging itself as a modifiable process amenable to intervention ( A third perspective emerges from Russian gerontological research, which has developed and clinically used peptides such as epitalon and Semax for decades with apparent success ( 7.2 Controversies and safety considerations The peptide landscape in gerontology is fraught with controversy

doi:10.3389/fcvm.2022.952430 Krijthe BP, de Jong FH, Hofman A, et al

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Wen Y, Chen H, Zhang L, Wu M, Zhang F, Yang D, Shen J, Chen J (2021) Glycyrrhetinic acid induces oxidative/nitrative stress and drives ferroptosis through activating NADPH oxidases and iNOS, and depriving glutathione in triple-negative breast cancer cells

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