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UDCA was also shown to normalize excessive myeloperoxidase activity and reactive oxygen species (ROS) production in stressed rat livers by enhancing the intracellular levels of a reduced form of glutathione [39]

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Microglia are also a source of the highly toxic peroxynitrite ( 2 ), a reactive nitrogen species (RNS) toxic to both neurons and oligodendrocytes ( FIGURE 1 Oxidative stress is an imbalance between generated ROS and innate antioxidants

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