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Performance might be improved further by testing allele combinations in a compound-heterozygous diploid model system

at 4mg per administration, roughly 20

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In the four-component Ugi reaction, the five different isocyanide derivatives of 4-hydroxythalidomide, in the presence of tritylamine or methylamine, formaldehyde, and acid-containing derivative of the target ligand (JQ1 derivative) yielded different anti-BRD4 PROTACs 178