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PMID: 39804166

In addition, there are various secondary enzymes such as glutathione reductase, glucose-6-phosphate dehydrogenase, and cytosolic GST that function to decrease peroxide levels or to maintain a steady supply of metabolic intermediates like glutathione (GSH) and NADPH for optimum functioning of the primary antioxidant enzymes (Meister, 1992) [81]

Last, the ECL2 lid possesses a key and exclusive residue R197 ECL2 in CCK1R, leading to a positively charged sub-pocket for TYS

Additionally, GSH precursors like N-acetylcysteine (NAC) have shown promise in enhancing endogenous GSH synthesis and minimizing oxidative damage in diabetes

Sci Rep 6:20953 Steudel R, Strauss E-M (1984) Homocyclic selenium molecules and related cations

[DOI] [PMC free article] [PubMed] [Google Scholar] 37.Cirillo M., Fucci R., Rubini S., Coccia M.E., Fatini C