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We also carried out a translational approach and examined the potential of a prolonged treatment with the GSH booster NAC to improve motivation

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The duration of action of a drug, time to steady state levels, and time to washout are each influenced by the value of the drug half-life

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Acknowledgements This work was supported by the Industrial Core Technology Development Program (10049112, Development of the Validation System for Efficacy Studies using Mini Pigs) funded by the Ministry of Trade, Industry & Energy (MOTIE, Korea)

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Phase II study of the safety and antitumor activity of the hypoxia-activated prodrug th-302 in combination with doxorubicin in patients with advanced soft tissue sarcoma

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