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Tremors, bradykinesia, and postural instability manifest following a 7080% depletion of dopaminergic neurons in the substantia nigra (SN) [3] and subsequently, dopamine release in the striatum is impaired [4]

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Limitations: Narrative review rather than systematic review with meta-analysis

The genomic DNA was amplified with two pairs of primers for the wild type and the mutant alleles: Wild-type forward primer: 5-GCTGTGGTCATGTGACAAGG-3

Inactivation of the GSTA4 Gene Inactivation of the GSTA4 gene was carried out using the lentiCRISPRv2 system (Addgene, MA, USA) (24)

18 en 2002 y Whitfield y cols